0618 - Osteogenic Protein 1 (op-1) Increases Bone Graft Incorporation Which Is Delayed by Morselization and Impaction
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چکیده
Introduction The use of morselized impacted cancellous allografts for hip arthroplasty revision surgery shows results which seem to differ dramatically from other kinds of allografting (1,2). In structural cancellous allografts, bone ingrowth is usually limited to 2-3 mm (3), whereas the whole of morselized impacted grafts seem to be remodelled in several cases as judged by radiography (1,4). In a previous study (5), we found that impaction of cancellous bone grafts in a bone chamber in rats leads to decreased ingrowth of new bone after 6 weeks as compared to unimpacted grafts. In the present study we analyze whether this decrease represented a final loss of ingrowth or just a delay, and if it was possible to reverse the decrease by adding a bone morphogenic protein (OP-1).
منابع مشابه
No augmentation of morselized and impacted bone graft by OP-1 in a weight-bearing model.
INTRODUCTION Impacted morselized bone allograft is thought to be remodeled to a great extent. We have previously shown that load-bearing increases the remodeling of impacted morselized bone allografts in a rabbit knee prosthesis model. Bone Morphogenic Proteins (BMPs) also stimulate bone formation and bone allograft remodeling. In this study, our aim was to determine whether it was possible to ...
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Impacted bone allograft is often used in revision joint replacement. Hydroxyapatite granules have been suggested as a substitute or to enhance morcellised bone allograft. We hypothesised that adding osteogenic protein-1 to a composite of bone allograft and non-resorbable hydroxyapatite granules (ProOsteon) would improve the incorporation of bone and implant fixation. We also compared the respon...
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